By Eduardo Sobarzo-sanchez
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Additional resources for Alkaloids : biosynthesis, biological roles and health benefits
Santos, A. J. Moreno, J. Holy, and P. J. Oliveira, Mitochondrially targeted effects of berberine [Natural Yellow 18, 5,6-dihydro-9,10dimethoxybenzo(g)-1,3-benzodioxolo(5,6-a) quinolizinium] on K1735-M2 mouse melanoma cells: comparison with direct effects on isolated mitochondrial fractions. J. Pharmacol. Exp. , 323 (2007) 636-49.  C. V. Diogo, N. G. Machado, I. A. Barbosa, T. L. Serafim, A. Burgeiro, and P. J. Oliveira, Berberine as a promising safe anti-cancer agent - is there a role for mitochondria ?
However, excessive production of oxidants under physiological conditions leads to oxidative stress and from this way causes a plethora of detrimental abnormalities in body tissues [16-18]. Superoxide anions, hydrogen peroxide and the hydroxyl radicals are oxidants which are generated by one, two and three electrons losses during the reduction of oxygen to water . In addition, singlet oxygen is the first state of molecular oxygen which is known as highly reactive oxygen species. It easily reacts with singlet molecules .
Autophagy, 4 (2008) 534-6.  H. Zhang, M. Bosch-Marce, L. A. Shimoda, Y. S. Tan, J. H. Baek, J. B. Wesley, F. J. Gonzalez, and G. L. Semenza, Mitochondrial autophagy is an HIF-1-dependent adaptive metabolic response to hypoxia. J. Biol. , 283 (2008) 10892-903.  K. M. Rouschop, C. H. Ramaekers, M. B. Schaaf, T. G. Keulers, K. G. Savelkouls, P. Lambin, M. Koritzinsky, and B. G. Wouters, Autophagy is required during cycling hypoxia to lower production of reactive oxygen species. Radiother.
Alkaloids : biosynthesis, biological roles and health benefits by Eduardo Sobarzo-sanchez