By P. R. Lichtlen (auth.), Professor Dr. P. R. Lichtlen, Professor Dr. A. Reale (eds.)

ISBN-10: 3642854982

ISBN-13: 9783642854989

ISBN-10: 3642855008

ISBN-13: 9783642855009

As little as 30 years in the past, cardiovascular examine at Bayer was once only a small sideline with in an atmosphere ruled by means of chemotherapy learn, and merely 15 years in the past, Bayer's pharmaceutical enterprise used to be restrained to ecu and Latin Ameri­ can international locations, with revenues in cardiovascular prescription drugs with reference to 0. It is going with out asserting that Adalat has replaced the corporate as an entire in its study, improvement, and advertising and marketing, either in Germany and, most significantly, international­ vast. In examine and improvement, Adalat has led the way in which in to new parts similar to high blood pressure, acute neurology, dementia, atherosclerosis, and center failure. In pharmacology, Adalat was once current on the dawning of the second one phar­ macological revolution, which began from entire animal types and progres­ sed, through in vitro screening and pharmacological learn at the DHP receptor, right down to the molecular point with the cloning of calcium-channel proteins. Having the Adalat tale heavily in its early years as a bench scientist, allow me take this chance to thank the inventors, the scientists, and the investigators who've helped to faucet the large strength of calcium-channel blockade with dihyd­ ropyridines quite often and Adalat specifically. yet, good fortune are not vague our imaginative and prescient. there is not any explanation for us to relaxation on our laurels: it is going to take real concepts in cardiovascular examine to best the most efficient set by way of Adalat. allow us to take in the challenge.

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Communication and practical application of scientific findings), was indeed correct. Adalat was rewriting pharmaceutical marketing history. International Growth Phase Adalat has now been marketed in over 100 countries. The phase of international growth started after its launch in the initial countries in 1975. United States marketing-campaigns by licence-holders Pfizer started in 1982. Adalat was never absent from any international cardiologist' meetings. Trials were performed worldwide, and the results were presented at a number of international Adalat symposia.

This paper reflects on the essence of that discussion, provides new data, reviews essential literature published since that time, and indicates where our profession should orient itself for the immediate future, certainly now that 1993 is around the comer with its profound implications for European integration. A brief preview was sketched at the 1986 Mainz meeting of the ESC [1] and at other symposia. The primary conclusion is that whereas the financial consequences of these advances in cardiac research and development may have been ignored in the past, they cannot be disregarded any longer by cardiologists.

Costs should be inflated by approximately 40% to convert from 1983-1984 to 1988-1989 price levels. me as I am only a doctor" must now be considered old-fashioned and irrelevant. We are and must be involved in the effort to optimize the utilization of health care resources, and justifiably so, because much has been gained in terms of reduced morbidity and improved life expectancy. Research is paying off in this respect. On the other hand, to be held 100% responsible for these decisions and to be the only ones who, within a given budget for a given hospital, have to decide which patient is going to have life-saving therapy and which should be left out (and presumably left to die if therapy is withheld) is equally unacceptable.

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Adalat: A Comprehensive Review by P. R. Lichtlen (auth.), Professor Dr. P. R. Lichtlen, Professor Dr. A. Reale (eds.)


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